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Iberdomide promotes degradation of Aiolos and Ikaros proteins
Product Name DOTA-tris(t-Bu)ester-C6-acid Synonyms CAS Number n/a Related CAS Molecular Formula C35H65N5O9 Molecular Weight 699
The red-fluorescent 5(6)-TAMRA azide is an excellent alkyne-reactive fluorescent reagent for labeling alkyne-containing biological molecules through click chemitry
5 Purity (HPLC) >= 95% Solubility DMSO
Azide-Propionyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan dbco-hexanoyl Iberdomide promotes degradation of AiolosSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU
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