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Induced degradation of SNAP-fusion proteins
NCT02 is a molecular glue cyclin K degrader
VHL-SNAP2-5C is a SNAP PROteolysis TArgeting Chimera (SNAP-PROTAC)
SOLU-KNEX® cleavable linker features a Val-Ala dipeptide
MC-Gly-Gly-Phe-Gly-PAB(m-PEG4) oregon green Induced degradation of SNAP-fusion proteinsSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine (PSAR), to enhance aqueous solubility. Solubility and physicochemical properties can be
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