2'-O-4'-C-Locked-G(dmf) Phosphoramidite Amount/Package:0.25g / 30mL screwed bottle-28 "2′-fluoro-modified pyrimidines enhance affinity of

"2′-fluoro-modified pyrimidines enhance affinity of RNA oligonucleotides to HIV-1 reverse transcriptase

Johanna Kela

Hybridization probes

" Accounts of chemical research 44

2'-O-4'-C-Locked-G(dmf) Phosphoramidite Amount/Package:0.25g / 30mL screwed bottle-28 "2′-fluoro-modified pyrimidines enhance affinity of2 O 4 C Locked G(dmf) Phosphoramidite is a locked nucleic acid (LNA) phosphoramidite monomer for solid phase oligonucleotide synthesis. It contains a bicyclic ribose in which a methylene bridge connects the 2 oxygen (O) and 4 carbon (C), locking the sugar in a C3 endo conformation. It also contains a guanine (G) with dimethylformamidyl (dmf) base protection, a 5 dimethoxytrityl (DMT) group for 5 hydroxyl protection, and a cyanoethyl (CE) protecting